In times of distress, prayer serves as a sanctuary for the soul, offering solace and guidance when the heart is burdened. The Bible, rich with wisdom, extends a comforting hand through its verses, providing specific prayers for those who grapple with anxiety and seek restful slumber. It also teaches us the profound significance of approaching God with a heart of gratitude, especially when presenting our requests. This article seeks to unwrap the biblical approach to praying in times of anxiety, invoking nighttime peace, and the importance of thanksgiving in our prayers, weaving in the relevant scriptural verses that offer a beacon of hope and a firm foundation for these sacred conversations with God.